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Role of Lipoxygenases and Lipoxin A4/Annexin-1 Receptor in Gastric Protection Induced by 20% Ethanol or Sodium Salicylate in Rats

Authors
  • Peskar, Brigitta M.
  • Ehrlich, Karlheinz
  • Schuligoi, Rufina
  • Peskar, Bernhard A.
Type
Published Article
Journal
Pharmacology
Publisher
S. Karger AG
Publication Date
Oct 16, 2009
Volume
84
Issue
5
Pages
310–313
Identifiers
DOI: 10.1159/000248165
PMID: 19844131
Source
Karger
Keywords
License
Green
External links

Abstract

The role of cyclooxygenases and prostaglandins in experimental models of gastroprotection is well established. We investigated the effects of the 5-lipoxygenase inhibitor A63162, the 12-lipoxygenase inhibitor baicalein and the 15-lipoxygenase inhibitor PD146176 as well as the nonspecific lipoxin A4/annexin-1 antagonist Boc1 on adaptive protection induced by 20% ethanol against 70% ethanol, and on protection induced by sodium salicylate against the mucosal-damage-aggravating effects of celecoxib and dexamethasone during local ischemia-reperfusion in rats. It was found that both types of gastroprotection were antagonized by the lipoxygenase inhibitors and the lipoxin A4/annexin-1 antagonist in doses that have no direct damaging effect on gastric mucosa. The results suggest that not only cyclooxygenases, but also active lipoxygenases and, possibly, annexin-1 are required for these types of gastroprotection to occur.

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