Role of Lipoxygenases and Lipoxin A4/Annexin-1 Receptor in Gastric Protection Induced by 20% Ethanol or Sodium Salicylate in Rats
- Authors
- Type
- Published Article
- Journal
- Pharmacology
- Publisher
- S. Karger AG
- Publication Date
- Oct 16, 2009
- Volume
- 84
- Issue
- 5
- Pages
- 310–313
- Identifiers
- DOI: 10.1159/000248165
- PMID: 19844131
- Source
- Karger
- Keywords
- License
- Green
- External links
Abstract
The role of cyclooxygenases and prostaglandins in experimental models of gastroprotection is well established. We investigated the effects of the 5-lipoxygenase inhibitor A63162, the 12-lipoxygenase inhibitor baicalein and the 15-lipoxygenase inhibitor PD146176 as well as the nonspecific lipoxin A4/annexin-1 antagonist Boc1 on adaptive protection induced by 20% ethanol against 70% ethanol, and on protection induced by sodium salicylate against the mucosal-damage-aggravating effects of celecoxib and dexamethasone during local ischemia-reperfusion in rats. It was found that both types of gastroprotection were antagonized by the lipoxygenase inhibitors and the lipoxin A4/annexin-1 antagonist in doses that have no direct damaging effect on gastric mucosa. The results suggest that not only cyclooxygenases, but also active lipoxygenases and, possibly, annexin-1 are required for these types of gastroprotection to occur.