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The role of lipocalin-2 in age-related macular degeneration (AMD)

Authors
  • Ghosh, Sayan1
  • Stepicheva, Nadezda1
  • Yazdankhah, Meysam1
  • Shang, Peng1
  • Watson, Alan M.2
  • Hose, Stacey1
  • Liu, Haitao1
  • Weiss, Joseph1
  • Zigler, J. Samuel Jr3
  • Valapala, Mallika4
  • Watkins, Simon C.2
  • Sinha, Debasish1, 3, 1
  • 1 Children’s Hospital of University of Pittsburgh School of Medicine, One Children’s Hospital Drive, 4401 Penn Avenue, Pittsburgh, PA, 15224, USA , Pittsburgh (United States)
  • 2 University of Pittsburgh School of Medicine, Pittsburgh, PA, USA , Pittsburgh (United States)
  • 3 Johns Hopkins University School of Medicine, Baltimore, MD, USA , Baltimore (United States)
  • 4 Indiana University, Bloomington, IN, USA , Bloomington (United States)
Type
Published Article
Journal
Cellular and Molecular Life Sciences
Publisher
Springer-Verlag
Publication Date
Jan 04, 2020
Volume
77
Issue
5
Pages
835–851
Identifiers
DOI: 10.1007/s00018-019-03423-8
Source
Springer Nature
Keywords
License
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Abstract

Lipocalins are a family of secreted adipokines which play important roles in various biological processes. Lipocalin-2 (LCN-2) has been shown to be involved in acute and chronic inflammation. This particular protein is critical in the pathogenesis of several diseases including cancer, diabetes, obesity, and multiple sclerosis. Herein, we discuss the general molecular basis for the involvement of LCN-2 in acute infections and chronic disease progression and also ascertain the probable role of LCN-2 in ocular diseases, particularly in age-related macular degeneration (AMD). We elaborate on the signaling cascades which trigger LCN-2 upregulation in AMD and suggest therapeutic strategies for targeting such pathways.

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