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Role of let-7b/Fzd4 axis in mitochondrial biogenesis through wnt signaling: In neonatal and adult megakaryocytes.

Authors
  • Undi, Ram Babu1
  • Gutti, Usha2
  • Gutti, Ravi Kumar3
  • 1 Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, (PO) Gachibowli, Hyderabad 500046, Telangana, India. , (India)
  • 2 Department of Biotechnology, GITAM Institute of Science, GITAM University, Visakhapatnam 530 045, Andhra Pradesh, India. , (India)
  • 3 Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, (PO) Gachibowli, Hyderabad 500046, Telangana, India. Electronic address: [email protected] , (India)
Type
Published Article
Journal
The international journal of biochemistry & cell biology
Publication Date
Oct 01, 2016
Volume
79
Pages
61–68
Identifiers
DOI: 10.1016/j.biocel.2016.08.009
PMID: 27510711
Source
Medline
Keywords
License
Unknown

Abstract

Our findings for the first time unveil the novel role of let-7b/Fzd4 axis through wnt signaling by regulating mitochondrial biogenesis during megakaryocyte development.

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