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[Role of let-7 in maintaining characteristics of breast cancer stem cells].

Authors
  • Sun, Xin
  • Fan, Chong
  • Hu, Li-juan
  • Du, Ning
  • Xu, Chong-wen
  • Ren, Hong
Type
Published Article
Journal
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Publication Date
Aug 01, 2012
Volume
28
Issue
8
Pages
789–792
Identifiers
PMID: 22863580
Source
Medline
License
Unknown

Abstract

SP sorting is an effective method to separate cancer stem cells. There do exist cancer stem cells in MCF-7 breast cancer cell line. Let-7 is down-regulated in SP cells, and the down-regulation makes let-7 lose the opportunity to restrain Ras mRNA, finally, p-Ras and p-ERK are activated. They play an important role in maintaining the characteristics of breast cancer stem cells.

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