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The role of isoprenoids in vascular smooth muscle: potential benefits of statins unrelated to cholesterol lowering.

Authors
Type
Published Article
Journal
Journal of human hypertension
Publication Date
Volume
10
Issue
6
Pages
387–390
Identifiers
PMID: 8872802
Source
Medline
License
Unknown

Abstract

Elevated plasma cholesterol is a well recognised risk factor for cardiovascular disease. Numerous studies have shown that a reduction in circulating cholesterol results in a reduced cardiovascular risk. The statins are a group of cholesterol lowering agents which act by inhibition of a key enzyme in cholesterol synthesis; 3-hydroxy 3-methyliglutaryl coenzyme A (HMG CoA) reductase. This enzyme is responsible for the conversion of HMG CoA to mevalonate. In addition to their efficacy as cholesterol lowering agents, statins inhibit the proliferation, migration and signalling of vascular smooth muscle cells. Inhibition of isoprenoid synthesis and resultant reduction in prenylation of key cellular proteins such members of p21ras and p21rho families may underlie some of these effects.

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