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Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats

Authors
  • Martiñón-Gutiérrez, Gabriel1
  • Luna-Castro, María1
  • Hernández-Muñoz, Rolando1
  • 1 Universidad Nacional Autónoma de México (UNAM), Ave. Universidad # 3000, Apdo. Postal 70-243, Coyoacán, Mexico City, 04510, Mexico , Mexico City (Mexico)
Type
Published Article
Journal
Scientific Reports
Publisher
Springer Nature
Publication Date
Jun 03, 2021
Volume
11
Issue
1
Identifiers
DOI: 10.1038/s41598-021-91228-w
Source
Springer Nature
License
Green

Abstract

The exposure to extremely low-frequency electromagnetic fields (EMFs) could adversely affect the endocrine system and cellular proliferative response. Nonetheless, the use of 60-Hz EMFs in the form of magneto-therapy exerts beneficial actions on human health but can also induce hyperglycaemia. Therefore, the present study was aimed to search for metabolic responses of fed or fasted male rats to a single EMF exposure. We performed a 15 min-single exposure to 60-Hz (3.8 mT, intensity) EMF, and determined serum levels of glucose, lipids, and indicators of cellular redox state and energy parameters. A single exposure to a 60-Hz EMF induced hyperglycaemia in both animal groups, and an attenuated second serum insulin peak. The 60-Hz EMF also decreased free fatty acids and lactate serum levels, oppositely increasing pyruvate and acetoacetate levels. Significant increases in blood glucose level and rat’s glucose metabolism were related to a more oxidized cellular redox state and variations in insulin and glucagon secretion. The 60-Hz EMF’s effects were not modified in animals previously subjected to chronic EMFs exposure (14 days). In conclusion, increased serum glucose levels and glucose metabolism induced by a single 60-Hz EMF exposure were closely related to the cellular redox state and the insulin/glucagon ratio.

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