Affordable Access

Access to the full text

Role of Inflammation in Retinal Microcirculation in Diabetic Eyes: Correlation between Aqueous Flare and Microvascular Findings

Authors
  • Celik Buyuktepe, Tuna
  • Özmert, Emin
  • Demirel, Sibel
  • Batıoğlu, Figen
Type
Published Article
Journal
Ophthalmologica
Publisher
S. Karger AG
Publication Date
Mar 11, 2020
Volume
243
Issue
5
Pages
391–398
Identifiers
DOI: 10.1159/000507089
PMID: 32160620
Source
Karger
Keywords
License
Green
External links

Abstract

Purpose: To investigate the correlation between aqueous flare and macular microvascular status assessed by optic coherence tomography angiography (OCTA) in diabetes mellitus. Methods: A cross-sectional study was conducted on 52 diabetic patients with nonproliferative retinopathy, 44 diabetic patients without retinopathy, and 20 nondiabetic age-matched controls. Spectral domain OCT, OCTA, and laser flare-cell meter were performed. Results: Compared to eyes without retinopathy, eyes with retinopathy had higher flare intensity (p = 0.024), enlarged capillary nonperfusion area (p < 0.001), and enlarged foveal avascular zone (p < 0.001). There was a significant correlation between flare intensity and capillary nonperfusion areas (p < 0.001, r = 0.511) and superficial capillary density (p = 0.005, r = –0.388) in diabetic eyes with retinopathy. Conclusion: The results demonstrated a positive correlation between aqueous flare levels, an indicator of intraocular inflammation, and microvascular damage demonstrated by OCTA in the early stages of diabetic retinopathy (DR). This finding supports the role of inflammation in the pathogenesis of DR.

Report this publication

Statistics

Seen <100 times