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The role of hypoxia-inducible factors in neovascular age-related macular degeneration: a gene therapy perspective

Authors
  • Mammadzada, Parviz1
  • Corredoira, Pablo M.1
  • André, Helder1
  • 1 St. Erik Eye Hospital,
Type
Published Article
Journal
Cellular and Molecular Life Sciences
Publisher
Springer-Verlag
Publication Date
Dec 31, 2019
Volume
77
Issue
5
Pages
819–833
Identifiers
DOI: 10.1007/s00018-019-03422-9
PMID: 31893312
PMCID: PMC7058677
Source
PubMed Central
Keywords
License
Unknown

Abstract

Understanding the mechanisms that underlie age-related macular degeneration (AMD) has led to the identification of key molecules. Hypoxia-inducible transcription factors (HIFs) have been associated with choroidal neovascularization and the progression of AMD into the neovascular clinical phenotype (nAMD). HIFs regulate the expression of multiple growth factors and cytokines involved in angiogenesis and inflammation, hallmarks of nAMD. This knowledge has propelled the development of a new group of therapeutic strategies focused on gene therapy. The present review provides an update on current gene therapies in ocular angiogenesis, particularly nAMD, from both basic and clinical perspectives.

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