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Role of hypothalamic monoamines in nicotine-induced anorexia in menopausal rats.

Authors
  • Zhang, L
  • Meguid, M M
  • Miyata, G
  • Varma, M
  • Fetissov, S O
Type
Published Article
Journal
Surgery
Publisher
Elsevier
Publication Date
Aug 01, 2001
Volume
130
Issue
2
Pages
133–142
Identifiers
PMID: 11490341
Source
Medline
License
Unknown

Abstract

In the presence of estradiol (ovary intact sham-operated rats), nicotine lowers food intake and body weight via increased LHA-DA and VMN-5-HT. In menopause (Ovx rats), nicotine lowers food intake and body weight only via increased VMN-DA and 5-HT. Data show that lower weight gain is mediated via changes in hypothalamic monoamines, primarily via ventromedial hypothalamus.

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