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The role of human achaete-scute homolog-1 in medullary thyroid cancer cells.

Authors
  • Sippel, Rebecca S1
  • Carpenter, Jennifer E
  • Kunnimalaiyaan, Muthusamy
  • Chen, Herbert
  • 1 Department of Surgery, The University of Wisconsin Medical School and the University of Wisconsin Comprehensive Cancer Center, 600 Highland Avenue, Madison, WI 53792, USA.
Type
Published Article
Journal
Surgery
Publisher
Elsevier
Publication Date
December 2003
Volume
134
Issue
6
Identifiers
PMID: 14668716
Source
Medline
License
Unknown

Abstract

hASH1 down-regulation by raf-1 in MTC cells is associated with a significant decrease in hormone production. Thus, hASH1 appears to be important in the endocrine phenotype of MTC tumors and may serve as a molecular target for the treatment of patients with MTC.

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