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Role of Histone Acetylation in Cell Cycle Regulation

Authors
Type
Published Article
Journal
Current Topics in Medicinal Chemistry
Publisher
Bentham Science
Publication Date
Nov 10, 2015
Volume
16
Issue
7
Identifiers
DOI: 10.2174/1568026615666150825140822
Source
LBMCC
Keywords
License
Yellow

Abstract

Core histone acetylation is a key prerequisite for chromatin decondensation and plays a pivotal role in regulation of chromatin structure, function and dynamics. The addition of acetyl groups disturbs histone/DNA interactions in the nucleosome and alters histone/histone interactions in the same or adjacent nucleosomes. Acetyl groups can also provide binding sites for recruitment of bromodomain (BRD)-containing non-histone readers and regulatory complexes to chromatin allowing them to perform distinct downstream …

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