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The role of gut-immune-brain signaling in substance use disorders.

Authors
  • Lucerne, Kelsey E1
  • Kiraly, Drew D2
  • 1 Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States. , (United States)
  • 2 Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: [email protected] , (United States)
Type
Published Article
Journal
International review of neurobiology
Publication Date
Jan 01, 2021
Volume
157
Pages
311–370
Identifiers
DOI: 10.1016/bs.irn.2020.09.005
PMID: 33648673
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Substance use disorders (SUDs) are debilitating neuropsychiatric conditions that exact enormous costs in terms of loss of life and individual suffering. While much progress has been made defining the neurocircuitry and intracellular signaling cascades that contribute to SUDs, these studies have yielded limited effective treatment options. This has prompted greater exploration of non-traditional targets in addiction. Emerging data suggest inputs from peripheral systems, such as the immune system and the gut microbiome, impact multiple neuropsychiatric diseases, including SUDs. Until recently the gut microbiome, peripheral immune system, and the CNS have been studied independently; however, current work shows the gut microbiome and immune system critically interact to modulate brain function. Additionally, the gut microbiome and immune system intimately regulate one another via extensive bidirectional communication. Accumulating evidence suggests an important role for gut-immune-brain communication in the pathogenesis of substance use disorders. Thus, a better understanding of gut-immune-brain signaling could yield important insight to addiction pathology and potential treatment options. Copyright © 2021 Elsevier Inc. All rights reserved.

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