Affordable Access

deepdyve-link
Publisher Website

Role of Granulocyte Colony-stimulating Factor Therapy in Cirrhosis, 'Inside Any Deep Asking Is the Answering'.

Authors
  • Philips, Cyriac Abby1
  • Augustine, Philip2
  • Ahamed, Rizwan2
  • Rajesh, Sasidharan3
  • George, Tom3
  • Valiathan, Gopakumar C4
  • John, Solomon K4
  • 1 The Liver Unit and Monarch Liver Lab, Cochin Gastroenterology Group, Ernakulam Medical Centre, Kochi, Kerala, India. , (India)
  • 2 Department of Gastroenterology, Cochin Gastroenterology Group, Ernakulam Medical Centre, Kochi, Kerala, India. , (India)
  • 3 Interventional Radiology, Hepatobiliary Division, Cochin Gastroenterology Group, Ernakulam Medical Centre, Kochi, Kerala, India. , (India)
  • 4 Department of Hepatobiliary and Transplant Surgery, Cochin Gastroenterology Group, Ernakulam Medical Centre, Kochi, Kerala, India. , (India)
Type
Published Article
Journal
Journal of clinical and translational hepatology
Publication Date
Dec 28, 2019
Volume
7
Issue
4
Pages
371–383
Identifiers
DOI: 10.14218/JCTH.2019.00034
PMID: 31915607
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Liver cirrhosis progresses through multiple clinical stages which culminate in either death or liver transplantation. Availability of organs, timely listing and prompt receipt of donor-livers pose difficulties in improving transplant-listed and transplant outcomes. In this regard, regenerative therapies, particularly with granulocyte colony-stimulating factor (GCSF), has become a lucrative option for improving transplant-free survival. However, the literature is confusing with regards to patient selection and real outcomes. In this exhaustive review, we describe the basics of liver fibrosis and cirrhosis through novel insights from a therapeutic point of view, discuss preclinical studies on GCSF in advanced liver disease to improve on clinical utility, shed light on the pertinent literature of GCSF in advanced cirrhosis, and provide astute inputs on growth factor therapy in decompensated cirrhosis. © 2019 Authors.

Report this publication

Statistics

Seen <100 times