Affordable Access

deepdyve-link
Publisher Website

The role of glucocorticoid and mineralocorticoid receptor DNA methylation in antenatal depression and infant stress regulation.

Authors
  • Galbally, Megan1
  • Watson, Stuart J2
  • van IJzendoorn, Marinus3
  • Saffery, Richard4
  • Ryan, Joanne5
  • de Kloet, Edo Ronald6
  • Oberlander, Tim F7
  • Lappas, Martha8
  • Lewis, Andrew J9
  • 1 School of Psychology and Exercise Science, Murdoch University, Australia; School of Medicine, University of Notre Dame, Australia; King Edward Memorial Hospital, Australia. Electronic address: [email protected] , (Australia)
  • 2 School of Psychology and Exercise Science, Murdoch University, Australia; School of Medicine, University of Notre Dame, Australia. , (Australia)
  • 3 Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Netherlands. , (Netherlands)
  • 4 Murdoch Children's Research Institute & Department of Paediatrics, The University of Melbourne, Australia. , (Australia)
  • 5 Murdoch Children's Research Institute & Department of Paediatrics, The University of Melbourne, Australia; Department of Epidemiology & Preventive Medicine, Monash University, Australia. , (Australia)
  • 6 Leiden University Medical Center, Leiden, Netherlands. , (Netherlands)
  • 7 Department of Pediatrics and School of Population and Public Health, Univeristy of British Columbia, Vancouver, BC, Canada. , (Canada)
  • 8 Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia. , (Australia)
  • 9 School of Psychology and Exercise Science, Murdoch University, Australia. , (Australia)
Type
Published Article
Journal
Psychoneuroendocrinology
Publication Date
Feb 08, 2020
Volume
115
Pages
104611–104611
Identifiers
DOI: 10.1016/j.psyneuen.2020.104611
PMID: 32087522
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Understanding fetal programming pathways that underpin the relationship between maternal and offspring mental health necessitates an exploration of potential role of epigenetic variation in early development. Two genes involved in stress response regulation, the glucocorticoid and mineralocorticoid receptors (NR3C1 and NR3C2) have been a focus in understanding stressful exposures and mental health outcomes. Data were obtained from 236 pregnant women from the Mercy Pregnancy Emotional Wellbeing Study (MPEWS), a selected pregnancy cohort, recruited in early pregnancy. Depression was measured using the Structured Clinical Interview for DSM-IV (SCID-IV) and repeated measures of the Edinburgh Postnatal Depression Scale (EPDS). Antidepressant use, stressful events and anxiety symptoms were measured. NR3C1 and NR3C2 DNA methylation was measured in placental and infant buccal samples. Infant cortisol was measured in repeat saliva samples across a task. This study found maternal early pregnancy depressive disorder and symptoms were associated with lower DNA methylation at NR3C2 CpG_24 in placental tissue. There were no significant differences for depression or antidepressant use for DNA methylation of NR3C1. Antenatal depression was associated with lower infant cortisol reactivity at 12 months. DNA methylation in CpG_24 site in NR3C2 in placental samples suppressed the relationship between early maternal depressive symptoms and infant cortisol reactivity. These findings show a relationship between antenatal depression, NR3C2 DNA methylation and infant cortisol response providing support for a specific fetal programming pathway. Further research is required to examine the stability of this epigenetic mark across childhood and long-term mental health outcomes. Copyright © 2020. Published by Elsevier Ltd.

Report this publication

Statistics

Seen <100 times