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A role of ghrelin in cancerogenesis.

Authors
  • Majchrzak, K
  • Szyszko, K
  • Pawłowski, K M
  • Motyl, T
  • Król, M
Type
Published Article
Journal
Polish journal of veterinary sciences
Publication Date
Jan 01, 2012
Volume
15
Issue
1
Pages
189–197
Identifiers
PMID: 22708377
Source
Medline
License
Unknown

Abstract

Ghrelin is a 28 amino-acid multi-functional peptide hormone, which was identified as a natural ligand of the growth hormone secretagogue receptor (GHS-R). Pituitary growth hormone-releasing activity in both animals and humans has been well documented. It has various biological functions, including regulation of appetite and body weight, control of energy homeostasis, modulation of cardiovascular and gastrointestinal system and anti-inflammatory effect. However, both ghrelin and its receptor (GHS-R) are widely distributed in various tumors, which strongly implies their role in neoplastic cell growth trough autocrine/paracrine mechanism. Multiple studies have demonstrated the role of ghrelin in cancer cells proliferation, differentiation, invasiveness and apoptosis inhibition. The ghrelin axis is more complex than it was originally thought and consist of several compounds that might interact with each other and affect ghrelin activities. Here, we provide an overview of the ghrelin and its receptor role in tumor progression.

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