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Role of free radicals and lipid peroxidation in gastric mucosal injury induced by ischemia-reperfusion in rats.

Authors
Type
Published Article
Journal
Scandinavian journal of gastroenterology. Supplement
Publication Date
Volume
162
Pages
55–58
Identifiers
PMID: 2595307
Source
Medline
License
Unknown

Abstract

Ischemia and reperfusion are of the greatest importance in the pathology of many diseases. We investigated the roles of oxygen-derived free radicals and lipid peroxidation in gastric mucosal injury, such as spotty and linear hemorrhagic erosions, induced in rats by ischemia-reperfusion. The gastric mucosal injury and the increase in thiobarbituric acid (TBA) reactants in the gastric mucosa induced by ischemia-reperfusion were significantly inhibited by treatment with SOD and catalase. These results suggest that oxygen-derived free radicals and lipid peroxidation play important roles in the pathogenesis of acute gastric mucosal lesions induced by ischemia-reperfusion.

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