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The role of extracellular vesicles in osteoarthritis treatment via microenvironment regulation.

Authors
  • Yin, Han1
  • Li, Muzhe1, 2
  • Tian, Guangzhao1, 3
  • Ma, Yang1
  • Ning, Chao1
  • Yan, Zineng1
  • Wu, Jiang1
  • Ge, Qian4
  • Sui, Xiang1
  • Liu, Shuyun5
  • Zheng, Jinxuan6
  • Guo, Weimin7
  • Guo, Quanyi8
  • 1 Institute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing, 100853, PR China. , (China)
  • 2 Department of Orthopedics, The First Affiliated Hospital of University of South China, Hengyang, 421000, China. , (China)
  • 3 School of Medicine, Nankai University, Tianjin, 300071, China. , (China)
  • 4 Huaiyin People's Hospital of Huai'an, Huai'an, 223001, China. , (China)
  • 5 Institute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing, 100853, PR China. [email protected]. , (China)
  • 6 Department of Orthodontics, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-Sen University, No.56 Linyuan Xi Road, Yuexiu District, Guangzhou, Guangdong, 510055, People's Republic of China. [email protected]. , (China)
  • 7 Department of Orthopaedic Surgery, Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, First Affiliated Hospital, Sun Yat-Sen University, No.58 Zhongshan Second Road, Yuexiu District, Guangzhou, 510080, Guangdong, China. [email protected]. , (China)
  • 8 Institute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing, 100853, PR China. [email protected]. , (China)
Type
Published Article
Journal
Biomaterials research
Publication Date
Oct 05, 2022
Volume
26
Issue
1
Pages
52–52
Identifiers
DOI: 10.1186/s40824-022-00300-7
PMID: 36199125
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Osteoarthritis (OA) is a degenerative joint disease that is common among the middle-aged and older populations, causes patients to experience recurrent pain in their joints and negatively affects their quality of life. Currently, therapeutic options for patients with OA consist of medications to alleviate pain and treat the symptoms; however, due to typically poor outcomes, patients with advanced OA are unlikely to avoid joint replacement. In recent years, several studies have linked disrupted homeostasis of the joint cavity microenvironment to the development of OA. Recently, extracellular vesicles (EVs) have received increasing attention in the field of OA. EVs are natural nano-microcarrier materials with unique biological activity that are produced by cells through paracrine action. They are composed of lipid bilayers that contain physiologically active molecules, such as nucleic acids and proteins. Moreover, EVs may participate in local and distal intercellular and intracellular communication. EVs have also recently been shown to influence OA development by regulating biochemical factors in the OA microenvironmental. In this article, we first describe the microenvironment of OA. Then, we provide an overview of EVs, summarize the main types used for the treatment of OA, and describe their mechanisms. Next, we review clinical studies using EVs for OA treatment. Finally, the specific mechanism underlying the application of miRNA-enriched EVs in OA therapy is described. © 2022. The Author(s).

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