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Role of ethnicity in antipsychotic-induced weight gain and tardive dyskinesia: genes or environment?

Authors
  • Chan, Lai Fong
  • Zai, Clement
  • Monda, Marcellino
  • Potkin, Steven
  • Kennedy, James L
  • Remington, Gary
  • Lieberman, Jeffrey
  • Meltzer, Herbert Y
  • De Luca, Vincenzo
Type
Published Article
Journal
Pharmacogenomics
Publication Date
Aug 01, 2013
Volume
14
Issue
11
Pages
1273–1281
Identifiers
DOI: 10.2217/pgs.13.127
PMID: 23930674
Source
Medline
License
Unknown

Abstract

Self-reported African-American ethnicity seemed to better predict AP-induced weight gain in schizophrenia compared with genetic ancestry, suggesting a possible role of environmental in addition to genetic factors. Future larger studies are needed to clarify specific gene-environment mechanisms mediating the effect of ethnicity on AP-induced weight gain.

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