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The role of estrogen in intervertebral disc degeneration.

Authors
  • Jin, Lin-Yu1
  • Song, Xiao-Xing2
  • Li, Xin-Feng3
  • 1 Department of Orthopaedic Surgery, Baoshan Branch of Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 1058, Huan Zheng Bei Rd, Shanghai 200444, P.R. China; Department of Spinal Surgery, Peking University People's Hospital, Peking University, Beijing 100044, China. , (China)
  • 2 Department of Anesthesiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Lu, Shanghai, 200025, China. Electronic address: [email protected] , (China)
  • 3 Department of Orthopaedic Surgery, Baoshan Branch of Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 1058, Huan Zheng Bei Rd, Shanghai 200444, P.R. China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Steroids
Publication Date
Dec 05, 2019
Pages
108549–108549
Identifiers
DOI: 10.1016/j.steroids.2019.108549
PMID: 31812622
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Intervertebral disc degeneration (IVDD) is a main contributor to low back and radicular pain, which imposes heavy economic burdens on society. However, the etiology and mechanism of IVDD are complex and still not completely clear. In particular, the role of estrogen in IVDD has not received much attention in recent research, although estrogen plays a crucial role in the metabolic dysfunction of others musculoskeletal structures, such as bone, muscle, and tendon. In this review, we attempt to describe the role of estrogen in IVDD and to summarize the proposed mechanisms in vivo and in vitro, as well as, to outline several interesting questions in this field. Copyright © 2019 Elsevier Inc. All rights reserved.

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