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[The role of endothelial cells and endothelial precursor cells in angiogenesis].

Authors
  • Poreba, Małgorzata
  • Usnarska-Zubkiewicz, Lidia
  • Kuliczkowski, Kazimierz
Type
Published Article
Journal
Przegla̧d lekarski
Publication Date
Jan 01, 2006
Volume
63
Issue
3
Pages
142–145
Identifiers
PMID: 16969899
Source
Medline
License
Unknown

Abstract

Endothelium plays a key role in maintenance of vascular homeostasis in human organism. According to new data endothelial cells and hematopoietic cells have a common precursor in prenatal life--a hemangioblast, which explains the fact of sharing the same determinants on the surface of both type of cells. Circulating endothelial precursors were identified in adults and this suggests that hemangioblasts may be present not only during embriogenesis. In some clinical situations the increased numbers of endothelial cells and endothelial precursors were noted, and especially in patients with neoplastic diseases, which is probably the result of increased angiogenesis. Endothelial precursors are thought to be the promice for therapeutic purposes in future--to increase local angiogenesis.

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