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A role for Dynlt3 in melanosome movement, distribution, acidity and transfer

Authors
  • Aktary, Zackie1, 2, 3
  • Conde-Perez, Alejandro1, 2, 3
  • Rambow, Florian1, 2, 3
  • Di Marco, Mathilde4
  • Amblard, François5, 6
  • Hurbain, Ilse4, 7
  • Raposo, Graça4, 7
  • Delevoye, Cédric4, 7
  • Coscoy, Sylvie5
  • Larue, Lionel1, 2, 3
  • 1 Normal and Pathological Development of Melanocytes, Institut Curie, CNRS UMR3347, Inserm U1021, Université PSL, Orsay, France , Orsay (France)
  • 2 Signalisation Radiobiologie et Cancer, CNRS UMR3347, Inserm U1021, Université Paris-Saclay, Orsay, France , Orsay (France)
  • 3 Equipe Labellisée – Ligue Contre le Cancer, Orsay, France , Orsay (France)
  • 4 CNRS UMR144, Structure and Membrane Compartments, Institut Curie, Centre National de la Recherche Scientifique, Paris Sciences & Lettres Research University, Paris, France , Paris (France)
  • 5 Laboratoire Physico-Chimie Curie, Institut Curie, PSL Research University - Sorbonne Universités, UPMC—CNRS, Paris, France , Paris (France)
  • 6 Departments of Bioengineering and Physics, Center for Soft and Living Matter, Institute for Basic Science (IBS), Ulsan National Institute of Science and Technology, Ulsan, South Korea , Ulsan (South Korea)
  • 7 CNRS UMR144, Cell and Tissue Imaging Facility, Institut Curie, Centre National de la Recherche Scientifique, Paris Sciences & Lettres Research University, Paris, France , Paris (France)
Type
Published Article
Journal
Communications Biology
Publisher
Nature Publishing Group UK
Publication Date
Mar 26, 2021
Volume
4
Issue
1
Identifiers
DOI: 10.1038/s42003-021-01917-5
Source
Springer Nature
License
Green

Abstract

Aktary et al. identify novel roles for the dynein light chain Dynlt3 in melanosome transport, maturation, and transfer to keratinocytes. They also find that the Wnt/βcatenin signalling pathway controls Dynlt3 levels and thus also contributes to the regulation of melanocyte transport and skin pigmentation.

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