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The role of cytotoxic T-cells in HIV infection.

Authors
  • Rowland-Jones, S
  • Dong, T
  • Krausa, P
  • Sutton, J
  • Newell, H
  • Ariyoshi, K
  • Gotch, F
  • Sabally, S
  • Corrah, T
  • Kimani, J
  • MacDonald, K
  • Plummer, F
  • Ndinya-Achola, J
  • Whittle, H
  • McMichael, A
Type
Published Article
Journal
Developments in biological standardization
Publication Date
Jan 01, 1998
Volume
92
Pages
209–214
Identifiers
PMID: 9554277
Source
Medline
Keywords
License
Unknown

Abstract

During the asymptomatic phase of HIV infection, HIV-specific cytotoxic T lymphocytes (CTL) are believed to play a major role in controlling virus levels. The design of an HIV vaccine requires knowledge about whether protective immunity can ever develop after exposure to the virus and the mechanisms underlying such natural immunity. The authors' research has focused on HIV-specific CTL responses in highly HIV-exposed commercial sex workers in The Gambia, West Africa, and in Nairobi, Kenya. HIV CTL was detected in 5 of 6 repeatedly exposed, persistently seronegative female sex workers in The Gambia. Their CTL recognized epitopes presented by HLA-835 that are cross-reactive between HIV-1 and HIV-2, suggesting they could have been primed first by HIV-2 exposure and subsequently boosted by exposure to HIV-1. Through use of previously identified clade B HIV-1 epitope peptides, the authors also detected HIV-specific CTL in 6 of 15 highly exposed and apparently resistant Kenyan prostitutes, predominantly toward epitopes highly conserved between B and Kenyan A and D clades of HIV-1. This CTL activity toward conserved virus epitopes may represent protective immunity to HIV in response to HIV generated by repeated exposure. HIV vaccines should aim to generate similar CTL responses. There is currently no evidence that genetic factors, other than weak HLA associations, influence susceptibility or resistance to HIV infection.

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