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Role of cyclic AMP in the inhibition of human platelet aggregation by quercetin, a flavonoid that potentiates the effect of prostacyclin

Authors
  • Beretz, Alain
  • Stierle, Anita
  • Anton, Robert
  • Cazenave, Jean-Pierre
Type
Published Article
Journal
Biochemical Pharmacology
Publisher
Elsevier
Publication Date
Jan 01, 1982
Accepted Date
May 07, 1982
Volume
31
Issue
22
Pages
3597–3600
Identifiers
DOI: 10.1016/0006-2952(82)90581-0
Source
Elsevier
License
Unknown

Abstract

Quercetin (3,3′,4′,5,7-pentahydroxyflavone) has previously been shown to inhibit cyclic nucleotide phosphodiesterases prepared from various cell homogenates and the function of intact human platelets. We now report that (1) high concentrations of quercetin raise platelet cAMP levels; and (2) quercetin potentiates the inhibitory effect of prostacyclin (PGI 2) on ADP-induced washed human platelet aggregation and the elevation of platelet cAMP levels elicited by PGI 2. These results suggest a role for cAMP in the mechanism of action of quercetin on blood platelets.

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