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The role of CD8 and CD4 T cells in intestinal allograft rejection: a comparison of monoclonal antibody-treated and knockout mice.

Authors
  • He, G
  • Hart, J
  • Kim, O S
  • Szot, G L
  • Siegel, C T
  • Thistlethwaite, J R
  • Newell, K A
Type
Published Article
Journal
Transplantation Journal
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jan 15, 1999
Volume
67
Issue
1
Pages
131–137
Identifiers
PMID: 9921809
Source
Medline
License
Unknown

Abstract

These results demonstrate that the inhibition of intestinal allograft rejection associated with mAb treatment is not attributable solely to depletion of CD8 or CD4 T cells. Furthermore, anti-CD8 mAb administration did not induce donor-specific tolerance or cause nonspecific immune suppression, as indicated by the skin-grafting experiments. Our findings suggest that at least some depleting mAbs mediate their protective effect on allograft rejection via an alternative mechanism such as the induction of a regulatory cell population(s).

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