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Role of calcium oscillations in sperm physiology.

Authors
  • Mata-Martínez, Esperanza1
  • Sánchez-Cárdenas, Claudia2
  • Chávez, Julio C3
  • Guerrero, Adán4
  • Treviño, Claudia L5
  • Corkidi, Gabriel6
  • Montoya, Fernando7
  • Hernandez-Herrera, Paul8
  • Buffone, Mariano G9
  • Balestrini, Paula A10
  • Darszon, Alberto11
  • 1 Laboratorio de Fusión de Membranas y Exocitosis Acrosomal, Instituto de Histología y Embriología Dr. Mario H. Burgos (IHEM) Universidad Nacional de Cuyo, CONICET, Mendoza, Argentina. Electronic address: [email protected] , (Argentina)
  • 2 Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología (IBT), Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, Mexico. Electronic address: [email protected] , (Mexico)
  • 3 Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología (IBT), Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, Mexico. Electronic address: [email protected] , (Mexico)
  • 4 Laboratorio Nacional de Microscopía Avanzada, IBT, UNAM, Mexico. Electronic address: [email protected] , (Mexico)
  • 5 Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología (IBT), Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, Mexico. Electronic address: [email protected] , (Mexico)
  • 6 Departamento de Ingeniería Celular y Biocatálisis, Laboratorio de Imágenes y Visión por Computadora, IBT, UNAM, Mexico. Electronic address: [email protected] , (Mexico)
  • 7 Departamento de Ingeniería Celular y Biocatálisis, Laboratorio de Imágenes y Visión por Computadora, IBT, UNAM, Mexico. Electronic address: [email protected] , (Mexico)
  • 8 Departamento de Ingeniería Celular y Biocatálisis, Laboratorio de Imágenes y Visión por Computadora, IBT, UNAM, Mexico. Electronic address: [email protected] , (Mexico)
  • 9 Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. Electronic address: [email protected] , (Argentina)
  • 10 Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. Electronic address: [email protected] , (Argentina)
  • 11 Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología (IBT), Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, Mexico. Electronic address: [email protected] , (Mexico)
Type
Published Article
Journal
Bio Systems
Publication Date
Nov 01, 2021
Volume
209
Pages
104524–104524
Identifiers
DOI: 10.1016/j.biosystems.2021.104524
PMID: 34453988
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Intracellular Ca2+ is a key regulator of cell signaling and sperm are not the exception. Cells often use cytoplasmic Ca2+ concentration ([Ca2+]i) oscillations as a means to decodify external and internal information. [Ca2+]i oscillations faster than those usually found in other cells and correlated with flagellar beat were the first to be described in sperm in 1993 by Susan Suarez, in the boar. More than 20 years passed before similar [Ca2+]i oscillations were documented in human sperm, simultaneously examining their flagellar beat in three dimensions by Corkidi et al. 2017. On the other hand, 10 years after the discovery of the fast boar [Ca2+]i oscillations, slower ones triggered by compounds from the egg external envelope were found to regulate cell motility and chemotaxis in sperm from marine organisms. Today it is known that sperm display fast and slow spontaneous and agonist triggered [Ca2+]i oscillations. In mammalian sperm these Ca2+ transients may act like a multifaceted tool that regulates fundamental functions such as motility and acrosome reaction. This review covers the main sperm species and experimental conditions where [Ca2+]i oscillations have been described and discusses what is known about the transporters involved, their regulation and the physiological purpose of these oscillations. There is a lot to be learned regarding the origin, regulation and physiological relevance of these Ca2+ oscillations. Copyright © 2021 Elsevier B.V. All rights reserved.

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