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The role of autocrine motility factor in tumor and tumor microenvironment.

Authors
Type
Published Article
Journal
Cancer metastasis reviews
Publication Date
Volume
26
Issue
3-4
Pages
725–735
Identifiers
PMID: 17828376
Source
Medline
License
Unknown

Abstract

Autocrine motility factor (AMF) is a tumor-secreted cytokine and is abundant at tumor sites, where it may affect the process of tumor growth and metastasis. AMF is a multifunctional protein capable of affecting cell migration, invasion, proliferation, and survival, and possesses phosphoglucose isomerase activity and can catalyze the step in glycolysis and gluconeogenesis. Here, we review the role of AMF and tumor environment on malignant processes. The outcome of metastasis depends on multiple interactions between tumor cells and homeostatic mechanisms, therefore elucidation of the tumor/host interactions in the tumor microenvironment is essential in the development of new prevention and treatment strategies. Such knowledge might provide clues to develop new future therapeutic approaches for human cancers.

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