[Role of angiotensin II receptors in proliferation of fibroblast derived from human hypertrophic scars].
- Authors
- Type
- Published Article
- Journal
- Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery
- Publication Date
- Jan 01, 2007
- Volume
- 23
- Issue
- 1
- Pages
- 36–39
- Identifiers
- PMID: 17393691
- Source
- Medline
- License
- Unknown
Abstract
Both AT1 and AT2 receptors were expressed in the fibroblasts of hypertrophic scars, and Ang II regulates DNA synthesis in hypertrophic scar fibroblasts through a negative cross-talk between AT1 and AT2 receptors, which might contribute, at least partly to formation and maturation of human hypertrophic scars. The present study provides new insight into pathogenesis of hypertrophic scars.
