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Role of Ancillary Techniques in Thyroid Cytology Specimens

Authors
  • Nishino, Michiya
  • Krane, Jeffrey F.
Type
Published Article
Journal
Acta Cytologica
Publisher
S. Karger AG
Publication Date
Apr 04, 2019
Volume
64
Issue
1-2
Pages
40–51
Identifiers
DOI: 10.1159/000496502
PMID: 30947167
Source
Karger
Keywords
License
Green
External links

Abstract

Ancillary molecular testing has emerged as a promising way to refine the preoperative risk stratification of thyroid nodules with indeterminate fine needle aspiration (FNA) biopsy results. Commercially available molecular tests for thyroid FNAs include those that analyze samples for mutations and gene fusions, gene expression alterations, microRNA expression alterations, chromosomal copy number alterations, or a combination thereof. This review summarizes the performance characteristics of the most current iterations of three tests currently marketed for cytologically indeterminate thyroid nodules: ThyroSeq v3, ThyGeNEXT/ThyraMIR, and Afirma Gene Sequencing Classifier.

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