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Role of Ancillary Techniques in Gynecologic Cytopathology Specimens

Authors
  • Olivas, Andrea D.
  • Barroeta, Julieta E.
  • Lastra, Ricardo R.
Type
Published Article
Journal
Acta Cytologica
Publisher
S. Karger AG
Publication Date
Mar 19, 2019
Volume
64
Issue
1-2
Pages
63–70
Identifiers
DOI: 10.1159/000496569
PMID: 30889579
Source
Karger
Keywords
License
Green
External links

Abstract

The association between high-risk genotypes of human papillomavirus (hr-HPV) and cervical cancer is well established. As hr-HPV testing is rapidly becoming a part of routine cervical cancer screening, either in conjunction with cytology or as primary testing, the management of hr-HPV-positive women has to be tailored in a way that increases the detection of cervical abnormalities while decreasing unnecessary colposcopic biopsies or other invasive procedures. In this review, we discuss the overall utility and strategies of hr-HPV testing, as well as the advantages and limitations of potential triage strategies for hr-HPV-positive women, including HPV genotyping, p16/Ki-67 dual staining, and methylation assays.

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