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[The role of adenosine Al receptors and mitochondrial K+ATP channels in the mechanism of increasing the resistance to acute hypoxia in the combined effects of hypoxia and hypercapnia].

Authors
  • Tregub, P P
  • Kulikov, V P
  • Stepanova, L A
  • Zabrodina, A S
  • Nagibaeva, M E
Type
Published Article
Journal
Patologicheskaia fiziologiia i èksperimental'naia terapiia
Publication Date
Jan 01, 2014
Issue
4
Pages
48–52
Identifiers
PMID: 25980226
Source
Medline
License
Unknown

Abstract

We studied the role of the role of mitoK+ATp channels and Al-adenosine receptor in the mechanism of increasing the resistance to acute hypoxia after hypoxic, hypercapnic and hypercapnic-hypoxic preconditioning. It is shown that mitochondrial ATP-sensitive potassium channels and Al-adenosine receptors, an important mechanism of preconditioning have a high value to increase the resistance to acute hypoxia/ischemia in the combined effect of hypoxia and hypercapnia. However, with regard to the adenosine receptor, this mechanism is realized without the participation hypercapnic component, which apparently starts neuroprotection without activation of the adenosine Al receptors.

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