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The role of acetylcholine in the cognitive function of frontal neurons in monkeys.

Authors
  • Liu, J L
  • Su, S N
Type
Published Article
Journal
Science in China. Series B, Chemistry, life sciences & earth sciences
Publication Date
Dec 01, 1993
Volume
36
Issue
12
Pages
1510–1517
Identifiers
PMID: 8129838
Source
Medline
License
Unknown

Abstract

To study the role of acetylcholine (ACh) in the cognitive function of frontal lobes, ACh and atropine were applied iontophoretically to the task-related neurons recorded from an area around the superior ramus of arcuate sulcus in the frontal cortex of 4 rhesus monkeys during the performance of two tasks. The spontaneous discharges and task-related responses of most of the neurons which increased their discharge rate in the delay and differentiation periods of the discrimination response go/no-go task and in the cue and delay periods of the delayed discrimination go/no-go task, were further increased during the application of ACh and suppressed during atropine. These results suggest that ACh may be involved in the excitatory process of the activity of the neurons in the above-mentioned area of frontal cortex to play an important role in the cognitive functions of attention, discrimination and short-term memory.

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