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[Role of 5-alpha-androstane-3-beta, 17-beta-diol in establishing feedback between the gonads and hypothalamo-hypophyseal system of orchidectomized adult rats].

Authors
  • Loseva, L A
  • Degtiar', V G
  • Isachenkov, V A
Type
Published Article
Journal
Voprosy medit︠s︡inskoĭ khimii
Publication Date
Jan 01, 1980
Volume
26
Issue
3
Pages
398–402
Identifiers
PMID: 7006206
Source
Medline
License
Unknown

Abstract

Concentration of luteinizing hormone and content of luliberine were estimated, respectively, blood serum and in hypothalamic arccuate nucleus and median eminence of adult castrated rats after administration of testosterone, 5 alpha-androstane 3 beta, 17 beta diol and 5 alpha-androstane 3 alpha, 17 beta diol. Effect of testosterone and of its derivatives on hypothalamo-hypophysial system was distinctly dissimilar both in the intensity of the action and in the rate of its realization. 5 alpha-androstane 3 beta, 17 beta diol as well as testosterone and 5 alpha-androstane 3 alpha, 17 beta diol were shown to be active in the negative feedback mechanism between gonads and hypothalamo-hypophysial system; the effect of androgenes was dose-dependent.

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