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Role of the α7 Nicotinic Acetylcholine Receptor and RIC-3 in the Cholinergic Anti-inflammatory Pathway.

Authors
  • Millet, Treinin1
  • Roger, Papke L2
  • Eran, Nizri3
  • Yael, Ben-David1
  • Tehila, Mizrachi4
  • Talma, Brenner4
  • 1 Department of Medical Neurobiology, Hebrew University - Hadassah Medical School, Jerusalem, Israel. , (Israel)
  • 2 Department of Pharmacology and Therapeutics, University of Florida, Gainesville, United States. , (United States)
  • 3 Department of General Surgery, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel. , (Israel)
  • 4 Department of Neurology, The Agnes Ginges Center for human Neurogenetics, Hadassah University Hospital and Hebrew University Medical School, Jerusalem, Israel. , (Israel)
Type
Published Article
Journal
Central nervous system agents in medicinal chemistry
Publication Date
Jan 01, 2017
Volume
17
Issue
2
Pages
90–99
Identifiers
DOI: 10.2174/1871524916666160829114533
PMID: 27573666
Source
Medline
Keywords
License
Unknown

Abstract

In this review we describe effects and mechanism of action of α7 nAChR and RIC-3 in the immune cholinergic system. Elucidating these mechanisms and the regulation of α7 and RIC-3 in the immune cholinergic system can pave the way for novel immunomodulatory agents, or towards extending the application of cholinergic agents.

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