Affordable Access

Rod photopigment deficits in albinos are specific to mammals and arise during retinal development.

Authors
  • Grant, S
  • Patel, N N
  • Philp, A R
  • Grey, C N
  • Lucas, R D
  • Foster, R G
  • Bowmaker, J K
  • Jeffery, G
Type
Published Article
Journal
Visual neuroscience
Publication Date
Jan 01, 2001
Volume
18
Issue
2
Pages
245–251
Identifiers
PMID: 11417799
Source
Medline
License
Unknown

Abstract

Adult albino mammals have specific retinal defects, including reduced numbers of rod photoreceptors. To examine when this rod deficit arises and whether it exists in nonmammalian albinos, we have used absorbance spectrophotometry to measure photopigment levels in dark-adapted eyes taken from three groups of pigmented and albino animals: adult rodents (rats and mice), developing rats, and mature Xenopus frogs. Rhodopsin concentrations were consistently and significantly reduced in mammalian albinos compared to their wild-type counterparts from before the time of eye opening, but photopigment levels were similar in frogs of both pigmentation phenotypes. The results strongly suggest that deficits in the rod cell population arise early in development of the mammalian albino retina, but do not generalize to nonmammalian mutants lacking retinal melanin.

Report this publication

Statistics

Seen <100 times