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A robust super-tough biodegradable elastomer engineered by supramolecular ionic interactions.

Authors
  • Daemi, Hamed1
  • Rajabi-Zeleti, Sareh2
  • Sardon, Haritz3
  • Barikani, Mehdi4
  • Khademhosseini, Ali5
  • Baharvand, Hossein6
  • 1 Department of Polyurethane, Iran Polymer & Petrochemical Institute, Tehran, Iran; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute, Tehran, Iran. , (Iran)
  • 2 Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute, Tehran, Iran. , (Iran)
  • 3 Polymat, University of the Basque Country UPV/EHU Joxe Mari Korta Center, Avda. Tolosa 72, 20018 San Sebastian, Spain. , (Spain)
  • 4 Department of Polyurethane, Iran Polymer & Petrochemical Institute, Tehran, Iran. Electronic address: [email protected] , (Iran)
  • 5 Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA; Biomaterials Innovation Research Center, Biomedical Engineering Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.
  • 6 Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute, Tehran, Iran; Department of Developmental Biology, University of Science and Culture, ACECR, Tehran, Iran. Electronic address: [email protected] , (Iran)
Type
Published Article
Journal
Biomaterials
Publication Date
Apr 01, 2016
Volume
84
Pages
54–63
Identifiers
DOI: 10.1016/j.biomaterials.2016.01.025
PMID: 26803411
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Alginate-based supramolecular ionic polyurethanes (ASPUs) as mechanically tunable biomaterials with high strength and toughness in both dry and hydrated states are developed under metal-free conditions. The Young's modulus and tensile strength of ASPUs are tuned from 30 to 100 MPa, and 20 to 50 MPa, respectively. Interestingly, the ASPUs exhibit a small hysteresis loop, minimal loss of tensile strength and minimal creep deformation after 100 repetitive cycles which makes them of use for engineering of load-bearing tissues. This is the first report that describes a linear PU can resist a large number of cyclic stresses without significant stretching. These bio-based elastomers engineered by ionic interactions are biocompatible and biodegradable. The ASPUs demonstrate a similar in vivo degradation rate compared to polycaprolactone (PCL). These biomaterials also demonstrate a rapid self-healing and recovery after rupture, and have a linear biodegradation profile. Furthermore, histological examination of subcutaneous transplanted ASPUs after five months reveals low immunological response and low fibrosis. Copyright © 2016. Published by Elsevier Ltd.

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