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A robust prognostic gene expression signature for early stage lung adenocarcinoma

  • Krzystanek, Marcin
  • Moldvay, Judit
  • Szüts, David
  • Szallasi, Zoltan Imre
  • Eklund, Aron Charles
Publication Date
Jan 01, 2016
Online Research Database In Technology
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Stage I lung adenocarcinoma is usually not treated with adjuvant chemotherapy; however, around half of these patients do not survive 5 years. Therefore, a reliable prognostic biomarker for early stage patients would be critical to identify those most likely to benefit from early additional treatments. Several studies have searched for gene expression prognostic biomarkers for lung adenocarcinoma, but these have not yielded a widely accepted prognosticator. We analyzed gene expression from seven published lung adenocarcinoma cohorts for which we included only stage I and II patients who were not given adjuvant therapy. Seven genes consistently obtained statistical significance in Cox regression for overall survival. The combined signature has a weighted mean hazard ratio of 3.2 in all cohorts and 3.0 (C.I. 1.3-7.4, p

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