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Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation.

Authors
  • Wong, Gerard C L1, 2, 3
  • Antani, Jyot D4
  • Lele, Pushkar P4
  • Chen, Jing5
  • Nan, Beiyan6
  • Kühn, Marco J7
  • Persat, Alexandre7
  • Bru, Jean-Louis8
  • Høyland-Kroghsbo, Nina Molin9
  • Siryaporn, Albert8, 10
  • Conrad, Jacinta C11
  • Carrara, Francesco12
  • Yawata, Yutaka13, 14
  • Stocker, Roman12
  • V Brun, Yves15
  • Whitfield, Gregory B15
  • Lee, Calvin K1, 2, 3
  • de Anda, Jaime1, 2, 3
  • Schmidt, William C1, 2, 3
  • Golestanian, Ramin16, 17
  • And 22 more
  • 1 Department of Bioengineering, University of California-Los Angeles, Los Angeles, California, CA 90095, United States of America. , (United States)
  • 2 Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California, CA 90095, United States of America. , (United States)
  • 3 California NanoSystems Institute, University of California-Los Angeles, Los Angeles, California, CA 90095, United States of America. , (United States)
  • 4 Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843, United States of America. , (United States)
  • 5 Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA24061, United States of America. , (United States)
  • 6 Department of Biology, Texas A&M University, College Station, Texas, TX 77845, United States of America. , (United States)
  • 7 Institute of Bioengineering and Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. , (Switzerland)
  • 8 Department of Molecular Biology & Biochemistry, University of California-Irvine, California, CA 92697, United States of America. , (United States)
  • 9 Department of Plant and Environmental Sciences, University of Copenhagen, DK-1871 Frederiksberg, Denmark. , (Denmark)
  • 10 Department of Physics & Astronomy, University of California-Irvine, California, CA 92697, United States of America. , (United States)
  • 11 William A Brookshire Department of Chemical and Biomolecular Engineering, University of Houston, Houston, Texas, TX 77204, United States of America. , (United States)
  • 12 Institute of Environmental Engineering, Department of Civil, Environmental and Geomatic Engineering, ETH Zurich, 8093 Zurich, Switzerland. , (Switzerland)
  • 13 Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan. , (Japan)
  • 14 Microbiology Research Center for Sustainability, University of Tsukuba, 305-8572 Tsukuba, Japan. , (Japan)
  • 15 University of Montreal, Faculty of Medicine, Montreal, Quebec, H3C 3J7, Canada. , (Canada)
  • 16 Max Planck Institute for Dynamics and Self-Organization (MPIDS), D-37077 Göttingen, Germany. , (Germany)
  • 17 Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Oxford OX1 3PU, United Kingdom. , (United Kingdom)
  • 18 Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, United States of America. , (United States)
  • 19 Department of Microbiology and Environmental Toxicology, University of California-Santa Cruz, Santa Cruz, California, CA 95060, United States of America. , (United States)
  • 20 CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, People's Republic of China. , (China)
  • 21 Department of Plant and Microbial Biology, University of Zürich, 8008 Zürich, Switzerland. , (Switzerland)
  • 22 Department of Physics and Astronomy, University of Southern California, Los Angeles, California, CA 90089, United States of America. , (United States)
  • 23 Department of Chemistry, University of Southern California, Los Angeles, California, CA 90089, United States of America. , (United States)
  • 24 Department of Biological Sciences, University of Southern California, Los Angeles, California, CA 90089, United States of America. , (United States)
  • 25 Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, CT 06516, United States of America. , (United States)
  • 26 Microbial Sciences Institute, Yale University, New Haven, Connecticut, CT 06516, United States of America. , (United States)
  • 27 Department of Materials Science and Engineering, University of California-Irvine, Irvine, California CA 92697, United States of America. , (United States)
  • 28 Department of Chemistry, University of California-Irvine, Irvine, California, CA 92697, United States of America. , (United States)
  • 29 Department of Chemical and Biomolecular Engineering, University of California-Irvine, Irvine, California, CA 92697, United States of America. , (United States)
  • 30 Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, CT 06511, United States of America. , (United States)
  • 31 Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey, NJ 08544, United States of America. , (Jersey)
  • 32 Department of Molecular Biology, Princeton University, Princeton, New Jersey, NJ 08544, United States of America. , (Jersey)
  • 33 Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, NJ 08544, United States of America. , (Jersey)
  • 34 The Howard Hughes Medical Institute, Chevy Chase, Maryland MD 20815, United States of America. , (United States)
  • 35 Department of Physics and Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People's Republic of China. , (China)
  • 36 Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany. , (Germany)
  • 37 Department of Physics, Philipps-Universität Marburg, 35043 Marburg, Germany. , (Germany)
  • 38 Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, MA 02139-4307, United States of America. , (United States)
Type
Published Article
Journal
Physical Biology
Publisher
IOP Publishing
Publication Date
Jun 23, 2021
Volume
18
Issue
5
Identifiers
DOI: 10.1088/1478-3975/abdc0e
PMID: 33462162
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Bacterial biofilms are communities of bacteria that exist as aggregates that can adhere to surfaces or be free-standing. This complex, social mode of cellular organization is fundamental to the physiology of microbes and often exhibits surprising behavior. Bacterial biofilms are more than the sum of their parts: single-cell behavior has a complex relation to collective community behavior, in a manner perhaps cognate to the complex relation between atomic physics and condensed matter physics. Biofilm microbiology is a relatively young field by biology standards, but it has already attracted intense attention from physicists. Sometimes, this attention takes the form of seeing biofilms as inspiration for new physics. In this roadmap, we highlight the work of those who have taken the opposite strategy: we highlight the work of physicists and physical scientists who use physics to engage fundamental concepts in bacterial biofilm microbiology, including adhesion, sensing, motility, signaling, memory, energy flow, community formation and cooperativity. These contributions are juxtaposed with microbiologists who have made recent important discoveries on bacterial biofilms using state-of-the-art physical methods. The contributions to this roadmap exemplify how well physics and biology can be combined to achieve a new synthesis, rather than just a division of labor. Creative Commons Attribution license.

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