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RNA-Seq Analysis of Gene Expression, Viral Pathogen, and B-Cell/T-Cell Receptor Signatures in Complex Chronic Disease.

Authors
  • Bouquet, Jerome1
  • Gardy, Jennifer L2, 3
  • Brown, Scott4, 5
  • Pfeil, Jacob1
  • Miller, Ruth R3
  • Morshed, Muhammad6, 7
  • Avina-Zubieta, Antonio8
  • Shojania, Kam8
  • McCabe, Mark2
  • Parker, Shoshana9
  • Uyaguari, Miguel2
  • Federman, Scot1
  • Tang, Patrick10
  • Steiner, Ted11
  • Otterstater, Michael2, 3
  • Holt, Rob4
  • Moore, Richard4
  • Chiu, Charles Y1, 12
  • Patrick, David M2, 3
  • 1 Department of Laboratory Medicine, University of California, San Francisco, USA.
  • 2 Communicable Disease Prevention and Control Services, British Columbia Centre for Disease Control, Vancouver, BC, Canada. , (Canada)
  • 3 School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada. , (Canada)
  • 4 Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver, BC, Canada. , (Canada)
  • 5 Genome Science and Technology Program, University of British Columbia, Vancouver, BC, Canada. , (Canada)
  • 6 British Columbia Centre for Disease Control Public Health Laboratory, 655 W 12th Ave., Vancouver, British Columbia, Canada. , (Canada)
  • 7 Department of Pathology and Laboratory Medicine, University of British Columbia, 2211 Wesbrook Mall, Vancouver, British Columbia, Canada. , (Canada)
  • 8 Department of Medicine, Division of Rheumatology, University of British Columbia, Vancouver, BC, Canada. , (Canada)
  • 9 Centre for Health Evaluation Outcome Sciences, Vancouver, Canada. , (Canada)
  • 10 Department of Pathology, Sidra Medical and Research Centre, Doha, Qatar. , (Qatar)
  • 11 Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, Canada. , (Canada)
  • 12 Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, USA.
Type
Published Article
Journal
Clinical Infectious Diseases
Publisher
Oxford University Press
Publication Date
Feb 15, 2017
Volume
64
Issue
4
Pages
476–481
Identifiers
DOI: 10.1093/cid/ciw767
PMID: 28172519
Source
Medline
Keywords
License
Unknown

Abstract

Our observations do not support a theory of transcriptionally mediated immune cell dysregulation in CFS and ADCLS, at least outside of periods of acute symptom flares.

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