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RNA virus-encoded microRNAs: biogenesis, functions and perspectives on application

Authors
  • Zhan, Shoubin1
  • Wang, Yanbo1
  • Chen, Xi1
  • 1 NJU Advanced Institute of Life Sciences (NAILS), School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210023, China , Nanjing (China)
Type
Published Article
Journal
ExRNA
Publisher
BioMed Central
Publication Date
Oct 12, 2020
Volume
2
Issue
1
Identifiers
DOI: 10.1186/s41544-020-00056-z
Source
Springer Nature
Keywords
License
Green

Abstract

MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression at the posttranscriptional level and play a crucial role in development and many diseases. The discovery of miRNAs has greatly expanded our understanding of the intricate scenario of genome-wide regulation. Over the last two decades, hundreds of virus-encoded miRNAs have been identified, most of which are from DNA viruses. Although the number of reported RNA virus-derived miRNAs is increasing, current knowledge of their roles in physiological and pathological processes has remained lacking. In this review, we discuss the biogenesis and biological functions of RNA virus- encoded miRNAs and their proposed roles in virus-host interactions and further underscore their potential value in the diagnosis and treatment of viral diseases.

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