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RNA Sequencing of Peripheral Blood Revealed that the Neurotropic TRK Receptor Signaling Pathway Shows Apparent Correlation in Recovery Following Spinal Cord Injury at Small Cohort

Authors
  • Wang, Chunqing1
  • Lv, Hangzhou2
  • Li, Qing1
  • Gong, Ke1
  • Yang, Lei Luo1
  • Wei, Zean1
  • Pan, Yujie1
  • Wang, Mingyong3
  • 1 the Affiliated Hospital of Guizhou Medical University, Department of Orthopedic Trauma, No 28, Guiyi Street, Guiyang City, 550001, China , Guiyang City (China)
  • 2 Jizhong Energy Xingtai MIG General Hospital, Department of Rehabilitation, No 202, Bayi Street, Xingtai City, 054001, China , Xingtai City (China)
  • 3 the Second Affiliated Hospital of Soochow University, Department of Orthopedics, Suzhou, 215004, China , Suzhou (China)
Type
Published Article
Journal
Journal of Molecular Neuroscience
Publisher
Springer-Verlag
Publication Date
Apr 16, 2019
Volume
68
Issue
2
Pages
221–233
Identifiers
DOI: 10.1007/s12031-019-01273-4
Source
Springer Nature
Keywords
License
Yellow

Abstract

Spinal cord injury (SCI) can be lethal; however, the precise mechanisms underlying healing are unclear, limiting the development of effective therapies. In this study, the molecular mechanisms involved in SCI were investigated. Clinical peripheral blood samples from normal individuals and patients with incomplete SCI (ISCI) and complete SCI (CSCI) were analyzed by RNA-Seq. The expression levels of EPHA4, CDK16, BAD, MAP2 Normal 2, EGR, and RHOB differed significantly between the SCI group and normal individuals, and these results were verified by q-PCR. A gene ontology (GO) enrichment analysis showed that differentially expressed genes were mostly enriched for the neurotrophin TRK receptor signaling pathway. We verified the expression of neurotrophic factors and found that they were all expressed most highly in the SCI group. The results of this study demonstrate that neurotrophic factors are highly expressed after SCI and the neurotrophin TRK receptor signaling pathway may be involved in the initiation of nerve system regeneration.

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