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RNA profiling of cyclooxygenases 1 and 2 in colorectal cancer.

Authors
  • Church, R D
  • Yu, J
  • Fleshman, J W
  • Shannon, W D
  • Govindan, R
  • McLeod, H L
Type
Published Article
Journal
British journal of cancer
Publication Date
Sep 13, 2004
Volume
91
Issue
6
Pages
1015–1018
Identifiers
PMID: 15328521
Source
Medline
License
Unknown

Abstract

Cyclooxygenases (particularily Cox-2) are involved in carcinogenesis and metastatic cancer progression. The expression profiles of the cyclooxygenases and the roles they play in established tumours of similar stage remains unclear. We report that Cox-1 and Cox-2 expression is highly variable in Dukes' C tumours, and changes in Cox-1 expression may be of importance.

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