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Bifunctional Enzyme JMJD6 Contributes to Multiple Disease Pathogenesis: New Twist on the Old Story.

Authors
  • Vangimalla, Shiva Shankar1, 2
  • Ganesan, Murali3, 4
  • Kharbanda, Kusum K5, 6
  • Osna, Natalia A7, 8
  • 1 Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, 4101 Woolworth Avenue, Omaha, NE 68105, USA. [email protected]
  • 2 Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA. [email protected]
  • 3 Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, 4101 Woolworth Avenue, Omaha, NE 68105, USA. [email protected]
  • 4 Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA. [email protected]
  • 5 Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, 4101 Woolworth Avenue, Omaha, NE 68105, USA. [email protected]
  • 6 Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA. [email protected]
  • 7 Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, 4101 Woolworth Avenue, Omaha, NE 68105, USA. [email protected]
  • 8 Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA. [email protected]
Type
Published Article
Journal
Biomolecules
Publisher
MDPI AG
Publication Date
Jun 01, 2017
Volume
7
Issue
2
Identifiers
DOI: 10.3390/biom7020041
PMID: 28587176
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Jumonji domain-containing protein 6 (JMJD6) is a non-heme Fe(II) 2-oxoglutarate (2OG)-dependent oxygenase with arginine demethylase and lysyl hydroxylase activities. Its initial discovery as a dispensable phosphatidylserine receptor (PSR) in the cell membrane of macrophages for phagocytosis was squashed by newer studies which revealed its nuclear localization and bifunctional enzymatic activity. Though its interaction with several nuclear and cytoplasmic target proteins has been demonstrated, the exact mechanisms and clinical significance of these various biologic interplays are not yet well established. Recent investigations have shed the light on the multiple pathways by which JMJD6 can regulate cell proliferation and cause tumorigenesis. Clinically, JMJD6 has been associated with more aggressive and metastatic disease, poorer prognosis, and lower overall survival rates-particularly in lung colon and oral cancers. JMJD6 is a novel biomarker for predicting future disease outcomes and is a target for new therapeutic treatments in future studies. Aberrant expression and dysregulation of JMJD6 are implicated in various other processes such as impaired T-cell proliferation and maturation, inoculation, and virulence of foot-and-mouth disease virus (FMDV), and impaired methylation of innate immunity factor. This article reviews the association of JMJD6 with various pathological processes-particularly, its role in tumorigenesis and virological interactions.

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