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Rituximab therapy leads to reduced imprints of receptor revision in immunoglobulin κ and λ light chains.

Authors
Type
Published Article
Journal
The Journal of rheumatology
Publication Date
Volume
39
Issue
6
Pages
1130–1138
Identifiers
DOI: 10.3899/jrheum.111513
PMID: 22505705
Source
Medline
License
Unknown

Abstract

Our data indicate that RTX therapy leads to generation of distinct Vκ/Jκ and Vλ/Jλ gene repertoires consistent with replenishment of antigen-experienced B cells by germinal centers. At baseline, the imprints of receptor revision appeared to be more striking, which indicates that receptor revision is active in patients with RA and can be reduced by RTX.

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