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The risks associated with aprotinin use: a retrospective study of cardiac cases in Nova Scotia.

Authors
  • Riddell, Robert E G
  • Buth, Karen J
  • Sullivan, John A
Type
Published Article
Journal
Canadian Journal of Anesthesia/Journal canadien d anesthésie
Publisher
Springer-Verlag
Publication Date
Jan 01, 2013
Volume
60
Issue
1
Pages
16–23
Identifiers
DOI: 10.1007/s12630-012-9806-5
PMID: 23132043
Source
Medline
License
Unknown

Abstract

Aprotinin was associated with an increased risk of in-hospital mortality and morbidity following cardiac surgery, and aprotinin was not associated with a decrease in blood product requirements. Continued use of aprotinin in cardiac surgery should follow careful consideration, weighing the demonstrated risks and potential advantages compared with other TXA.

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