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[Risk of type 2 diabetes mellitus among users of atypical antipsychotic drugs or conventional treatment: systematic review and meta-analysis].

Authors
  • Sapunar Z, Jorge
  • Muñoz N, Sergio
  • Vásquez A, Tatiana
Type
Published Article
Journal
Revista médica de Chile
Publisher
SciELO Comision Nacional de Investigacion Cientifica Y Tecnologica
Publication Date
Nov 01, 2009
Volume
137
Issue
11
Pages
1417–1426
Identifiers
DOI: /S0034-98872009001100002
PMID: 20098798
Source
Medline
License
Unknown

Abstract

Atypical antipsychotic drugs have less extra pyramidal side effects and are more effective to control the clinical manifestations of schizophrenia. However, their use may be associated to a higher incidence of weight gain, dyslipidemia, metabolic syndrome, glucose intolerance and type 2 diabetes mellitus. We performed a systematic literature search to evaluate the risk of type 2 diabetes mellitus incidence associated to the use of atypical antipsychotic drugs, compared to conventional treatment. If users of all types of atypical antipsychotic drugs are compared with users of conventional treatment, no significant differences in the incidence of type 2 diabetes mellitus were observed. If individual drugs are evaluated, clozapine and risperidone are associated with a higher risk of diabetes than haloperidol. Quetiapine is associated with a lower risk of diabetes than conventional treatment. The quality of the evidence found was low; therefore, new studies should been performed.

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