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Risk of subsequent attention-deficit/hyperactivity disorder among children and adolescents with amalgam restorations: A nationwide longitudinal study.

  • Lin, Po-Yen1, 2
  • Wang, Jui3
  • Chiang, Yu-Chih4
  • Lai, Chen-Yin5
  • Chang, Hong-Ji6
  • Chi, Lin-Yang1, 7
  • 1 Department of Dentistry, School of Dentistry, National Yang-Ming University, Taipei, Taiwan. , (Taiwan)
  • 2 Department of Dentistry, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan. , (Taiwan)
  • 3 Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. , (Taiwan)
  • 4 Department of Restorative and Aesthetic Dentistry, School of Dentistry, National Taiwan University and National Taiwan University Hospital, Taipei, Taiwan. , (Taiwan)
  • 5 Kao Ku Lien Polyclinic, Taipei, Taiwan. , (Taiwan)
  • 6 Department of Dentistry, Cheng Hsin General Hospital, Taipei, Taiwan. , (Taiwan)
  • 7 Department of Education and Research, Taipei City Hospital, Taipei, Taiwan. , (Taiwan)
Published Article
Community dentistry and oral epidemiology
Publication Date
Aug 07, 2017
DOI: 10.1111/cdoe.12327
PMID: 28782290


The univariate analysis results showed that those who had 6 or more amalgam restorations had a 20% higher risk of future ADHD; however, the association disappeared after the model was adjusted for age. Despite this study analysing a larger sample than those analysed in previous studies, no association was observed between young patients' having received amalgam restorations and a future ADHD diagnosis. Further research aimed at evaluating the association between dental amalgam and other subsequent neuropsychological effects is warranted, especially for people who are vulnerable to mercury exposure.

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