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Risk of hypercalcemia in blacks taking hydrochlorothiazide and vitamin D.

Authors
  • Chandler, Paulette D1
  • Scott, Jamil B2
  • Drake, Bettina F3
  • Ng, Kimmie4
  • Forman, John P5
  • Chan, Andrew T6
  • Bennett, Gary G7
  • Hollis, Bruce W8
  • Giovannucci, Edward L9
  • Emmons, Karen M10
  • Fuchs, Charles S11
  • 1 Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass. Electronic address: [email protected]
  • 2 Department of Epidemiology and Biostatistics, Michigan State University, East Lansing.
  • 3 Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Mo.
  • 4 Harvard Medical School, Boston, Mass; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Mass.
  • 5 Harvard Medical School, Boston, Mass; Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.
  • 6 Harvard Medical School, Boston, Mass; Department of Gastroenterology, Massachusetts General Hospital, Boston, Mass; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Mass.
  • 7 Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Mass.
  • 8 Department of Psychology and Neuroscience, Duke University, Durham, NC.
  • 9 Harvard Medical School, Boston, Mass; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Mass; Division of Pediatrics, Medical University of South Carolina, Charleston.
  • 10 Harvard Medical School, Boston, Mass; Department of Nutrition, Harvard School of Public Health, Boston, Mass; Center for Community-Based Research, Dana-Farber Cancer Institute, Boston, Mass.
  • 11 Harvard Medical School, Boston, Mass; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Mass; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Mass.
Type
Published Article
Journal
The American journal of medicine
Publication Date
Aug 01, 2014
Volume
127
Issue
8
Pages
772–778
Identifiers
DOI: 10.1016/j.amjmed.2014.02.044
PMID: 24657333
Source
Medline
Keywords
License
Unknown

Abstract

In summary, vitamin D3 supplementation up to 4000 IU in hydrochlorothiazide users is associated with an increase in serum calcium but a low frequency of hypercalcemia. These findings suggest that participants of this population can use hydrochlorothiazide with up to 4000 IU of vitamin D3 daily and experience a low frequency of hypercalcemia.

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