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Risk Factors for Extended-Spectrum-β-Lactamase-Producing Escherichia coli in Community-Onset Bloodstream Infection: Impact on Long-Term Care Hospitals in Korea

Authors
  • Baek, Yae Jee
  • Kim, Young Ah
  • Kim, Dokyun
  • Shin, Jong Hee
  • Uh, Young
  • Shin, Kyeong Seob
  • Shin, Jeong Hwan
  • Jeong, Seok Hoon
  • Lee, Geun Woo
  • Lee, Eun Ji
  • Kim, Dong-Sook
  • Park, Yoon Soo
Type
Published Article
Journal
Annals of Laboratory Medicine
Publisher
Korean Society for Laboratory Medicine
Publication Date
Sep 01, 2021
Volume
41
Issue
5
Pages
455–462
Identifiers
DOI: 10.3343/alm.2021.41.5.455
PMID: 33824233
PMCID: PMC8041596
Source
PubMed Central
Keywords
Disciplines
  • Original Article
  • Clinical Microbiology
License
Unknown

Abstract

Background The prevalence of extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) in the community has increased worldwide due to multifactorial reasons. ESBL-EC bloodstream infection (BSI) complicates the decision for proper antimicrobial administration. In this multicenter study, we investigated the prevalence, risk factors, and molecular background of community-onset (CO) ESBL-EC BSI. Methods We included data for all episodes of ESBL-EC BSI of community origin from May 2016 to April 2017 obtained from the Korean national antimicrobial resistance surveillance system, which comprises six sentinel hospitals. Data, including previous history of admission and use of antimicrobials and medical devices before BSI, were collected, along with microbiological analysis results. Results Among 1,189 patients with CO BSI caused by E. coli , 316 (27%) were identified as ESBL producers. History of admission, especially to a long-term care hospital (LTCH), and previous use of β-lactams/β-lactamase inhibitors, carbapenem, lincosamide, aminoglycoside, and extended-spectrum cephalosporin were independent risk factors for CO ESBL-EC BSI; admission to an LTCH showed the highest odds ratio (3.8, 95% confidence interval 2.3-6.1). The most common genotype was CTX-M-15 (N=131, 41%), followed by CTX-M-14 (N=86, 27%). ST131 was the most common sequence type among ESBL-EC groups (57%). Conclusions In Korea, 27% of CO E. coli BSI were caused by ESBL producers. From perspectives of empirical treatment and infection control, history of admission to an LTCH and antimicrobial use should be noted.

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