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Risk factors for acute graft-versus-host disease in patients undergoing transplantation with CD34+ selected blood cells from HLA-identical siblings.

Authors
  • Urbano-Ispizua, Alvaro
  • Rozman, Ciril
  • Pimentel, Pedro
  • Solano, Carlos
  • de la Rubia, Javier
  • Brunet, Salut
  • Pérez-Oteyza, Jaime
  • Ferrá, Christelle
  • Zuazu, Javier
  • Caballero, Dolores
  • Bargay, Joan
  • Carvalhais, Alzira
  • Díez, Jose Luis
  • Espigado, Ildefonso
  • Alegre, Adrián
  • Rovira, Montserrat
  • Campilho, Fernando
  • Odriozola, Jesús
  • Sanz, Miguel Angel
  • Sierra, Jordi
  • And 3 more
Type
Published Article
Journal
Blood
Publication Date
Jul 15, 2002
Volume
100
Issue
2
Pages
724–727
Identifiers
PMID: 12091376
Source
Medline
License
Unknown

Abstract

A study on 315 patients undergoing transplantation with CD34+ selected blood cells from HLA-identical siblings was performed to determine risk factors for acute GVHD (aGVHD). Recipients of a dose of CD34+ cells (x 10(6)/kg) of 2 or less, more than 2 to 4, and more than 4 had a cumulative incidence of aGVHD grades I-IV of 21%, 35%, and 43%, respectively (log-rank P =.01); similarly, recipients of a dose of CD3+ cells (x 10(6)/kg) of 0.05 or less, more than 0.05 to 0.1, and more than 0.1 had a cumulative incidence of aGVHD grades I-IV of 18%, 35%, and 44%, respectively (log-rank P =.007). Using a Cox regression model, 4 independent factors for aGVHD I-IV were identified: increased CD34+ cell dose (P =.02), increased CD3+ cell dose (P =.02), female patients (P =.01), and higher patient age (> 42 years) (P =.007). This study shows, for the first time in T-cell-depleted transplantations, a positive correlation between the number of CD34+ cells and aGVHD and, also, that the number of CD3+ cells necessary to initiate aGVHD is lower than previously reported.

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