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Risk of diabetes and hypertension in a population with alcohol use disorders.

  • Tseng, Pei-Ying1, 2
  • Sung, Fung-Chang3, 4, 5
  • Muo, Chih-Hsin3
  • Lan, Yu-Ching6
  • Hser, Yih-Ing7
  • Chien, Sarina Hui-Lin8
  • Wang, Jong-Yi9
  • 1 Department of Public Health, China Medical University, 406, Taichung, Taiwan. , (China)
  • 2 Department of Medicine, Lee's General Hospital, 358, Yuanli, Taiwan. , (Taiwan)
  • 3 Management Office for Health Data, China Medical University Hospital, 404, Taichung, Taiwan. , (China)
  • 4 Department of Health Services Administration, China Medical University College of Public Health, 406, Taichung, Taiwan. , (China)
  • 5 Department of Food Nutrition and Health Biotechnology, Asia University, 413, Taichung, Taiwan. , (Taiwan)
  • 6 Expert Labs, IBM Taiwan Corporation, 110, Taipei, Taiwan. , (Taiwan)
  • 7 Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 90095, Los Angeles, CA, USA.
  • 8 Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan. , (China)
  • 9 Department of Health Services Administration, China Medical University, 100 Jingmao Rd. Sec. 1, Beitun Dist, 406, Taichung, Taiwan. [email protected]. , (China)
Published Article
BMC Public Health
Springer (Biomed Central Ltd.)
Publication Date
Mar 21, 2024
DOI: 10.1186/s12889-024-18318-y
PMID: 38515085


A population-based follow-up study assessing the risk of developing hypertension and diabetes associated with alcohol use disorder (AUD) is crucial. We investigated this relationship by using insurance claims data from Taiwan. From the claims data, an AUD cohort (N = 60,590) diagnosed between 2000 and 2006 and a non-AUD comparison cohort (N = 60,590) without the diagnosis of hypertension or diabetes at baseline were established and matched by propensity scores estimated by baseline demographic status and the Charlson comorbidity index (CCI). We assessed the incidence rates of hypertension and/or diabetes at the end of 2016 and used Cox's method to estimate the related hazard ratios (HRs) and 95% confidence intervals (CIs). Relative to the comparison cohort, the AUD cohort had an approximately 1.70-fold higher incidence of hypertension (35.1 vs. 20.7 per 1,000 person-years), with an adjusted HR (aHR) of 1.72 (95% CI: 1.68-1.76), 2.16-fold higher incidence of diabetes (20.2 vs. 9.36 per 1,000 person-years), with an aHR of 2.18 (95% CI: 2.11-2.24), and 1.91-fold higher incidence of both diabetes and hypertension (10.3 vs. 5.38 per 1,000 person-years) with an aHR of 2.02 (95% CI: 1.94-2.10). The incidence rates of all outcomes were greater in men than in women, whereas the HRs were greater for AUD in women than for AUD in men relative to the respective comparison patients. The risk increased further for subjects with CCI ≥ 1, which was higher in the AUD cohort. The increased risk of developing diabetes and hypertension in patients with AUD, especially the differences noted according to gender, indicates that clinicians should address potential comorbidities in these patients. © 2024. The Author(s).

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